A Trusted Choice for Healthy Longevity
Blue California’s flagship ingredient, ErgoActive® ergothioneine, is a cutting-edge ingredient that supports mitochondrial, cellular and whole-body health. ErgoActive® is clinically shown to boost body levels of ergothioneine that normally decline with aging.
- Clinically supported, continued investment into science: double-blinded randomized placebo-controlled studies, with additional studies in the pipeline at top academic research institutions
- Ease of formulation: water-soluble with neutral taste and exceptional stability
- Advanced Technology: with our proprietary precision fermentation technologies to produce nature-identical bio-based ergothioneine
- Applications: dietary supplement, food, beverage, cosmetic and pet nutrition
- Safety: first bio-based ergothioneine to achieve FDA-reviewed GRAS (#734) in 2019
Embracing Healthy Longevity
The global population over age 65 is expanding rapidly, driven by declining birth rates and rising life expectancies. Modern consumers increasingly recognize the importance of extending healthspan—the years spent in good health—as a cornerstone of a longevity-focused lifestyle.
Inspired by nature, we create innovative nutritional ingredients designed to support the vitality and well-being consumers need to lead happy, healthy lives.
What is L-Ergothioneine?
The late renowned biochemist Bruce Ames has designated ergothioneine as a “longevity vitamin,” highlighting its role in preventing long-term health issues and premature aging.
Although important for combating aging, ergothioneine must be obtained through dietary sources like mushrooms or supplementation.
Ergothioneine’s unique molecular structure ensures exceptional stability and enduring antioxidant protection, making it ideal for formulations targeting oxidative stress. Unlike many water-soluble vitamins, ergothioneine is highly bioavailable and retained in the body, with a dedicated Ergothioneine Transporter (ETT) delivering it directly to cells and mitochondria for maximum impact.
Health benefits of ErgoActive®
Due to the unique features of ergothioneine, its health benefits are vast and multifaceted. Health benefits of ErgoActive® may include:
Mitochondrial Health
Cell-Protection
Telomere Protection
Cognitive Support
Eye Health
Immune Support
Sleep Support
ErgoActive® for Healthy Longevity and Telomere Support
Telomeres, the protective endcaps of chromosomes, are key indicators of aging. These structures naturally shorten with each cell division and as we age. This process can be accelerated by factors such as stress, smoking, poor nutrition, infections, and disease.
In a first-of-kind study, ErgoActive® was evaluated for its potential to support telomere integrity in cultured human fibroblasts under both normal conditions and oxidative stress. Compared to controls, ErgoActive® treatment:
- Resulted in longer median telomere length
- Reduced percentage of short telomeres
- Slowed the rate of telomere shortening
These results highlight the ability of ErgoActive® in counteracting oxidative stress-related telomere damage, offering a promising pathway to healthier aging and cellular resilience.
ErgoActive®: The Next Breakthrough in Cognitive Health
With aging, blood levels of crucial nutrients like ergothioneine decline. Suboptimal levels of ergothioneine in the body is consistently linked to significant age-related health concerns, including cognitive decline. Raising ergothioneine levels is associated with health benefits.
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- A study with 2,840 participants aged 60+ showed that higher mushroom consumption, a natural source of ergothioneine, correlated with better cognitive performance.
- A study with 470 adults aged 50+ showed that higher plasma ergothioneine levels was associated with enhanced memory and executive function.
- Lower blood ergothioneine levels have been observed in patients with mild cognitive impairment and dementia.
- A study involving 92 healthy adults between 40 to 75 years showed that ergothioneine supplementation improved sleep quality.
Blue California is pleased to announce completion of a double-blinded placebo-controlled clinical trial on ErgoActive® ergothioneine supplementation. This landmark study underscores the potential of ErgoActive® to support cognitive health, memory, and sleep in the healthy elderly with subjective memory complaints.
ErgoActive® Applications
Dietary Supplements
Functional Foods
Beverages
Gummies
Cosmetic Applications
