Blue California Publishes Research on the Protective Effects of Taxifolin, a Bioactive Plant Flavonoid
New findings show that Taxifolin BC-DHQ® supplementation may support healthy immune function and antioxidant defense in models of inflammation.
Rancho Santa Margarita, Calif. (Jan. 8, 2024) – Blue California is excited to announce the publication of a recent study titled, "Taxifolin Inhibits NETosis through Activation of Nrf2 and Provides Protective Effects in Models of Lupus and Antiphospholipid Syndrome," in Rheumatology. This study explores the potential immune-supporting and antioxidant benefits of Taxifolin, a bioactive plant flavonoid, in preclinical models.
The initial results were presented by Dr. Ramadan Ali, co-author of the study and researcher from the University of Michigan, at the ACR Convergence 2022.
Key results from the study include:
Taxifolin (dihydroquercetin), a natural flavonoid known for its antioxidative properties, was studied for its potential to support immune function and a balanced inflammatory response. The research sheds light on how taxifolin influences a process called NETosis—a mechanism related to immune cell activity that plays a role in inflammation.
- Support for Healthy Immune Function: The study found that Taxifolin, at low concentrations (0.1 to 1 µg/ml), supported healthy immune cell activity by inhibiting NETosis in laboratory assays. The flavonoid’s effects were linked to the activation of Nrf2, a protein known for its role in cellular defense against oxidative stress.
- Research on Immune Balance: In preclinical models, including those simulating lupus and antiphospholipid syndrome (APS), Taxifolin was observed to help maintain immune balance and promote overall antioxidant health. These models also suggested a potential reduction in the formation of neutrophil extracellular traps (NETs) and support for healthy large-vein function.
- Antioxidant Benefits and Inflammatory Support: Taxifolin supplementation in these models appeared to reduce oxidative stress and support a balanced inflammatory response. This research aligns with ongoing studies on the broader health benefits of dietary antioxidants.
These findings provide exciting insights into how Taxifolin may support immune balance and antioxidant defense, particularly in complex inflammatory models like lupus and APS," said Dr. Linda May-Zhang, co-author of the study and VP Science & Innovation at Blue California. "While more research is needed, these findings contribute to the growing body of evidence supporting taxifolin’s potential role in promoting overall health.
The study was also featured in Longevity.Technology magazine.
Conclusion:
Taxifolin’s ability to modulate immune activity and support antioxidant balance highlights its potential as a dietary supplement for maintaining healthy immune function. Blue California is committed to advancing the understanding of taxifolin and other bioactive compounds through research and innovation.
Blue California is a leader in the development of nature-based ingredients for dietary supplements, functional foods, and beverages. Our commitment to innovation and sustainability ensures that we provide high-quality ingredients, like Taxifolin BC-DHQ®, that support human health and wellness.
For more information, visit https://bluecal-ingredients.com
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